yes, it is not antibodies, but leptospira itself - see J Am Vet Med Assoc. 1954 Nov;125(932):381-2.

Isolation of Leptospira pomona from a bovine eye.

I agree that Leptospira can produce uveitis in cattle, but it is difficult to indicate what is exactly involved in the eye inflammation of cattle. Time after 1954...it has been demonstrated that some leptospiral proteins called LruA and LruB are expressed in uveitic eyes and that antibodies directed against those proteins also cross-react with components of eyes (auto immune reaction) causing the eye inflammation. It seems that such reactions may be found in many animals (see http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000778).

Dear Aswathy

I completely agree with the above two answers. I think it may be possible for the Leptospira antibodies to produce uveitis but the concentration of the bacteria in the cow should be very high or the cow should be repeatedly exposed to this bacteria in its life. I think if this is the case, then some other features should be seen in that cow such as hypersensitivity type 4. This is a very nice question and I think we need more focused investigations in this regard. To the knowledge of this researcher, there may be no experimental investigation shown that the antibodies of this bacteria could cause uveitis. We have similar situation in humans in which when the antibodies and antigens increase in the body, the rheumatoid arthritis could be developed in these cases. I think if this is the case, then the autoimmune response may be the mechanism. In fact the complex antibody-antigen is immunogenic and could cause inflammation.

What do you think about this idea?

Best regards

Dear all, i appreciate ur answers, the point is where lies the confirmation of the diagnosis; do it require simultaneous detection of the organism in blood, the antibodies or the complex in aqueous humor..