Can I do a DALI search using multiple chains?

25 July 2022 1 3K Report

I would like to find other protein structures in the PDB which resemble a structure my group recently solved. However, my structure contains two chains. I assume DALI (http://ekhidna2.biocenter.helsinki.fi/dali/) is not able to do it. Is there any other server that is able to do this search?

Annemarie Honegger

You would search with each chain separately. If the observed interaction is conserved, the resulting sets of PDB IDs should overlap, indicating entries in which homologs of both chains are present.

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