Can exosomes can be disrupted by sonication using a sonicator which is fixed strength water bath based? If so then for how long do you need to sonicate?
water bath sonication is often used to produce (lipid) vesicles; the longer the sonication the better the monodispersity. To "destroy" exosome-vesicles, I assume to use stronger power (desintegration sonicators) and short time.