It is known that 8-arginine vasopressin (AVP) and its analogue 1-deamino-8-D-arginine vasopressin (DDAVP) raise circulating vWF and FVIII levels in physiological conditions, and this is the basis for using desmopressin the management of Haemophilia A and von Willebrand disease.
Therefore, could elevated levels of ADH such as in states of chronic hyperosmolality/volume depletion stimulate and stabilise sufficient circulating factor VIII/vWF levels such that mild variants of Hemophilia A and von Willebrand disease (either congenital or acquired) can be masked?
Is relationship between chronic high pressure and coagulation factors??
Intisar Razzaq Sharba , my question wasn't related to chronic hypertension, rather acutely elevated ADH as may be seen in SIADH or volume depletion states, however since my query is specific to the relationship between ADH and coagulation factor VIII, it is open to any underlying disease states including chronically elevated blood pressure. If you have any insights please do share! Thanks
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