Can COMPUSYN calculate synergism for cytoprotective in vitro expriments? What factors should I consider while calculating drug synergism in compusyn?

12 December 2014 1 7K Report

I can see a significant cytoprotection in the combination(1:10) drug doses than the individual doses (approx. >17%, MTT assay values). I now need to find the CI values and DRI values along with relevant plots for further study. Can compusyn assist me with the job?

Enrique Barrajón-Catalán

Of course, as any pharmacological effect, cytoprotection can be used with Compusyn software. You only have to stablish the right control for cytoprotection and use good desogn for measure the activity (chekerboard disign for example).

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