Lot of papers on co-crystallization technique are there in literature to improve the solubility of BCS Class II drugs. can this be taken a Ph. D research project. Also request you to suggest newer BCS class II or IV drugs for the same purpose....
Hi Tanmoy,
There are many articles and reviews about cocrystallization of BCS Class II drugs. There is a themed collection on 'pharmaceutical solids' in Chemical Communications (http://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=cc&themeid=e501a497-d228-4de7-a1f1-6629d392281e) which can be helpful for you. Even there is so much literature existing in the literature, it is very difficult to suggest you the exact molecule/molecules for your Ph. D. project. If you go through the literature you will get ideas about to design your own project. One more suggestion is, as you are in the starting stage of your Ph. D., choose some of the molecules susceptible to cocrystallize (already have cocrystals). Basing on those existing cocrystals start screening with your own coformers, so that you should get some knowledge in designing your own molecules (if the results are good you'll end up with a nice paper as well).
While choosing the Class II drugs, go for the cheaper ones, once you gain your confidence you can go for the expensive ones. As you are from India, I can suggest the name Yarrow drugs (http://yarrowpharma.com/) who supplies in a reasonable prices (attached the catalogue when we purchased from them). You can also try to select the vitamins, nutraceuticals (with low solubility) which are very good compounds to think to design your Ph. D project.
Good luck.
thank you Sir for your guidance... i am looking for drug from yarrow pharma only as they are our supplier of drugs here in our Faculty. The concept of trying vitamins, nutraceuticals (with low solubility) looks interesting to me and i will surely check for its doability.... thanks Sir.....
Co-crystals consist of two or more molecules linked together with a hydrogen bond. The most appropriate co-crystal can be selected using a variety of analytical techniques and rational physicochemical studies. An example of hydrogen bond co-crystallization is co-crystals of aspirin, rac-ibuprofen and rac-flurbiprofen. These were prepared by disrupting the carboxylic acid dimmers using 4,4V-bipyridine. These structures are formally molecular compounds (or co-crystals) but do not involve in the formation of covalent bonds.
According to BCS classification, APIs belonging to BCS II and IV have problems in solubility/permeability. Hence, co-crystallization can be used to enhance their solubility/permeability. Therefore, the knowledge of crystallography along with the molecular properties of APIs can pose a great optional for solubility and permeability enhancement.
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