Whenever I am trying to do the reaction the keto group of Chalcone is reacting whereas the double bond is remaining intact.
Sir,
This literature can be of some use to you.
M.L.Leuva, V.M.Barot and Vikesh Agrawal
Synthesis, Characterization and Biological Activity of Pyrazolines
Journal of Chemical, Biological and Physical Sciences, May 2013- July 2013; Vol. 3, No. 3; 1678-1683.
Available online at www.jcbsc.org
Section A: Chemical Science
Wishing you good success
Using Michael addition you can activate the beta-carbon of alpha,beta-unsaturated carbonyl compound. When nucleophiles react with alpha,beta-unsaturated carbonyl compounds, the beta carbon will activated.
Sir, Amer I need to react the double bond with a homoenolate....but in my case the homoenolate attacks the keto carbonyl group instead of the double bond.
This is going to depend heavily on the nature and reactivity of your homoenolate. If you are using a metalated system then addition of Cu(I) salts is often beneficial in achieving your desired selectivity. It is difficult to give further advice without more knowledge of the system.
Addition of TMSCl may also help promote the desired 1,4-addition, again depending on your system.
Eric do you have any reference related to addition of Cu(I) or TMSCl. Please share.
Das,
For copper-catalysed Michael reaction please see
--- Csizmadiova, Jana; Meciarova, Maria; Almassy, Ambroz; et al. J. ORGANOMETALLIC CHEM. 737, 47-52, 2013
--- Perez, Elisabet; Moreno-Manas, Marcial; Maria Sebastian, Rosa; et al. EUR. J. INORG. CHEM.1013-1019, 2010
Good luck
Activation of double bond of Chalcone , Introduce electron with drawing group at o/p-position in the Phenyl ring.
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