I couldn't find any references for knee meniscus cell metabolic or gene expression pathways. For degradation many pathways are reported. Can anyone share research about it ?
Dear Mamatha following papers may help:
1. Transcriptome analysis of injured human meniscus reveals a distinct phenotype of meniscus degeneration with aging.
http://www.ncbi.nlm.nih.gov/pubmed/23658108
2. Expression of Phosphocitrate-Targeted Genes in Osteoarthritis Menisci
http://www.hindawi.com/journals/bmri/2014/210469/
3. Characterisation of human knee meniscus cell phenotype
http://www.oarsijournal.com/article/S1063-4584(05)00050-6/abstract
4. Changes of human menisci in osteoarthritic knee joints
http://www.oarsijournal.com/article/S1063-4584(10)00205-0/abstract
5. Analysis of meniscal degeneration and meniscal gene expression
http://www.biomedcentral.com/1471-2474/11/19
6. Electrical stimulation enhances cell migration and integrative repair in the meniscus
http://www.nature.com/articles/srep03674
7. Characterisation of human meniscus cells
http://www.ncbi.nlm.nih.gov/pubmed/16625447
8. Human meniscal proteoglycan metabolism in long-term tissue culture
http://link.springer.com/article/10.1007%2FBF01566000
9. Advances in Meniscal Tissue Engineering
http://www.hindawi.com/journals/sci/2012/420346/
10. Meniscus repair using mesenchymal stem cells – a comprehensive review
http://www.stemcellres.com/content/6/1/86
11. Chemical changes of human knee joint menisci in various stages of degeneration
http://www.ard.bmj.com/content/43/4/635.full.pdf
12. The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration
http://pubmedcentralcanada.ca/pmcc/articles/PMC3161498/
13. Current Concepts in Synovial Tissue of the Knee Joint
http://www.healio.com/orthopedics/knee/journals/ortho/2008-2-31-2/%7B06da86cf-3ac6-4fe7-850f-1170c97e9403%7D/current-concepts-in-synovial-tissue-of-the-knee-joint
14. Osteoarthritis in the XXIst Century: Risk Factors andBehaviours that Influence Disease Onset and Progression
http://www.mdpi.com/1422-0067/16/3/6093/pdf
Aamir
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