I had gone through certain procedures. Some used rare stabilizers like plant extracts (which are not easily accessible), copolymers or the synthetic procedures are vague like they did not mentioned how they synthesized PLA precursor.
Here is one good review. It should be possible to optimize the size.
http://www.sciencedirect.com/science/article/pii/S0168365900003394
pretty muc all of them can make nanoparticles that small. I mainly depends upon your design of experiments ( Chemistry route, solvent extraction, leaching etc etc). The choice of solvent along with all the thermodynamic constrains dictate the final size of the particles. There are 1000's of biodegradable polymers so google " Biopolymers nanoparticles" and you will get all the required information
PLGA is the gold standard for biodegradable and biocompatible polymers. other polymers could be PLA, PGA... you just search these terms and you will find thousands of articles.
Use Chiotsan , its biodegradable and use sodium tipolyphosphate to make nano particles, parameters can be easily controlled
You can use a spray-dryer machine. It creates a spray (nano-drops) that forms solid nano-particles when the solvent into the nano-drops is removed by high temperature. You can change formulation parameters (mass of polymer, volume of solvent, pressure in the pump of the system, etc) to get different sizes of the NP. In addition, the technique is very useful when you want to encapsulate hydrophilic molecules.
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