I am looking for the thermal degradation pathway and products of 6-mercaptopurine (Temp.: 200-1000 Celsius, Inert atmosphere).
Any relevant reading suggestions are also much appreciated. Thanks.
Hi Nagapradeep,
do you have access to a TG-MS-System? Alternatively you can try it with Pyrolysis-GC/MS. Otherwise, it looks pretty bad to get these data.
Regards
Markus
No, I don't have access to neither of those systems.
Any how, thanks for taking time in posting your response.
Polyhydroxyalkanoates (PHAs) are bacterial polyeste ars used in the production of biodegradable plastics. PHAs accumulate in bacterial cells under nutrient-limited conditions in response to excess carbon . The thiopurine drugs, including azathioprine, 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), are purinergic antimetabolite agents with profound antiproliferative effects. Azathioprine is converted into 6-MP, whose enzymatically driven metabolites 6-thioguanine nucleotides and 6-methylmercaptopurine interfere with RNA, DNA and protein synthesis as well as promote apoptosis of proliferating T cells. Numerous mechanisms are involved in the antiproliferative effects of 6-MP, which include its incorporation into nucleic acids chains. In addition, recent evidence indicates that 6-MP inhibits the phosphatidylinositol 3 kinase (PI3K) / mammalian target of rapamycin (mTOR) signaling pathway, suggesting that these drugs might interfere with metabolic checkpoints and impact metabolic reprogramming in normal T cells and cancer. The possible role in cell metabolic reprogramming, 6-MP regulates the activity of members of the orphan nuclear receptor NR4A family, which acts as key transcriptional regulators of glucose and lipid metabolism.
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