Can anyone recommend a CW laser system of 808 nm that I can use to treat rats injected with nanoparticles. I have a portable CW diode laser (Chanchung New Industries Opto electronics Tech.co. Ltd) but I am not convinced that this could be used to illuminate the whole tumor in the animal.
What is the power density required for this application and what is the area of the tumor?
Hi Robert,
I may need a power density of 2.5 W cm-1 covering an area of 1 cm (approximate area)
I recommend you use this laser .... http://www.edmundoptics.com/lasers/fiber-coupled-lasers/class-iv-high-power-fiber-coupled-laser-systems/33039/ .
I used to work for the laser manufacture and it should work perfect based on your requirements.
http://www.edmundoptics.com/lasers/fiber-coupled-lasers/class-iv-high-power-fiber-coupled-laser-systems/33039/
Common error in this case - assume that the nanoparticles hotter than the tumor in average. Therefore, the nanoparticles are unnecessary. The same effect can be achieved by changing the wavelength of the radiation.
Dear Boris,
The idea is to kill the tumor cells through the heat produced by NPs (widely known as photothermal therapy). And at this NIR wavelenghth, tissue absorb very minimum light which wont be sufficient to kill the cells. so, the nanoparticle and the laser, both work as a combo in destroying tumor cells.
This idea is well known to me. It is wrong to begin with. It is surprising that so many researchers do not understand this. Probably because they do not physicists.
Photothermal therapy only makes sense when heated nanoparticles using very short laser pulses, rather than continuous radiation.
In the case of continuous exposure, we are dealing with a conventional laser hyperthermia, nanoparticles here only affect the absorption coefficient of the tissue. The same effect can be obtained by changing the wavelength of irradiation without nanoparticles.
Thanks Boris. So do you mean I should go for a pulsed laser instead of a continuous laser?
Yes. Required irradiation parameters depend on the absorption cross section and size of nanoparticles.
Hi Boris, I am going to use Goldnanorods (LSPR- 680 to 720 nm) and I have not found one laser system yet.
You want to develop a medicine or just do scientific work?
Please e-mail me on address: [email protected]
try diode laser with NIR range. low power lasers only available.but it is enough for therapy.Otherwise you need to go for Ti-Sapphire laser for this wavelength
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