Can anyone provide IC50 values of temozolomide and doxorubicin against U87 Glioblastoma cells from cells survival assay (after 72 hours)?
as well as against normal glial cells or normal skin fibroblast
and what is the highest concentration that we must to be work on it
Dear Hamzeh!
Please You look at the article:
Article In Vitro Radiosensitizing Effects of Temozolomide on U87MG C...
Data analysis for lethal dose and IC50 value of TMZ treated cells showed that by increasing the dose of TMZ from 1,000 to 8,000 µM, the cell death rate was increased and up to 50% cytotoxicity was seen in up to 4000 µM doses (figure 2).
Article The DNA damage/repair cascade in glioblastoma cell lines aft...
Table I
Cell lines with the IC50 values for each drug and the MGMT and p53 gene status.
Cell line IC50 (μM)a for TMZ (μM)a for Dox (μM)
U87-MG 170.0 0.92 μM
Hello
Check the following to get the IC50 of drugs according to the cell lines.
www.cancerrxgene.org
Hope that helps
Hello. This review would be helpful to your question: https://doi.org/10.1186/s12885-021-08972-5. In short, IC50 values of TMZ are very variable.
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