Can anyone point to any studies (other than the one below) that suggest a loss of microbial diversity in a given habitat exacerbates the spread of ARGs, or that increasing microbial diversity (e.g. via inoculation) reduces ARGs?
https://link.springer.com/content/pdf/10.1007/s42832-019-0011-0.pdf
And/or if you have any general thoughts on this, please leave comments.
Thanks,
Jake
Dear colleague,
Please see this study:
https://www.nature.com/articles/s41598-017-14803-0
Article Sulfadiazine dissipation as a function of soil bacterial diversity
We discuss aspects of how the loss of microbial diversity impacts ecosystem functions, with a focus on the degradation of organic pollutants.
To date, I only know the work Chen et al. (2019) on this theme. Being that for 7 years I am inserted in the field of study microbial diversity and degradation of organic pollutants in the soil.
Article Antimicrobial susceptibility of bacterial isolates from the ...
Interesting question. Perturbations in host microbiome richness and diversity have been identified as a consequence of treatment with different antibiotics. But whether reduced microbiome richness and diversity in antibiotic-treated hosts are themselves direct causes of the spread of antibiotic resistance within a human population, the data appear limited. Human usage of antibiotics of antibiotics also increases the flow of antibiotic-resistant genes to clinically-relevant bacteria (see doi: 10.1007/s11684-017-0531-x). One could postulate that an enrichment of pathobionts e.g. Enterobacteriaceae sp, following antibiotic treatment, and a heightened selective pressure for antibiotic-resistant gene flow to the pathobiont, would be expected to increase the reservoir of antibiotic-resistant Enterobacteriaceae sp in a given population of patients. But sufficient data would be needed to link such antibiotic-resistant pathobiont enrichment in individual hosts to direct spread to confirmed non-antibiotic treated / non-antibiotic-resistant pathobiont harbouring persons.
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