Where can i find the best crystal structure for MRP1 (ABCC1)? Ideally with the binding site defined in a format that i can upload into MOE software. The Structure can be from bacterial/rodent/mammal or even a homology model.
I have tried looking at PDB and uniprot but with not much luck with obtaining the actual sequence for the protein. In particular for uniprot there are 15 sequences in mammals however i do not know which one to choose or how to extract the sequence to read it into the MOE software.
Any publications with this information but with access to the protein sequence will be greatly appreciated too!
Thanks for any help
Danielle
Hi Danielle,
the PDB is THE place to look for your structure. And following a quick search I see quite a few (related) structures). You can get the fasta sequence in the DIsplay/Download tab. If you wish to search for closest matches of a particular sequence in the PDB, you can either use BLAST, with the search restricted to the PDB database only, or, for example, the new SwissModel server (choose 'Search for Templates') http://swissmodel.expasy.org/interactive.
best of luck.
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