If a segment is deleted from a paternal chromosome it causes Prader-Willi Syndrome but if same segment is deleted from maternal chromosome it causes Angelman Syndrome.
What will be the results if segment is deleted from both parents?
Large deletions of the PWS/AS region would be homozygous lethal, but check out the recent paper about MAGEL2 (attached) which successfully identified this gene in the PWS region as part of the PWS phenotype. Although it would be predicted to be vanishingly rare it would be at least theoretically possible for someone to inherit mutations in this gene and UBE3A from father and mother respectively, and have a composite phenotype from unaffected parents.
Article Truncating mutations of MAGEL2cause Prader-Willi phenotypes and autism
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