First, state, as clearly as you can, a research question. For example: How does a new medication compare with a placebo in treating muscle pain? Then construct a research hypothesis. In this case, you might hypothesize that patients who receive the new medication for 12 weeks will experience less pain compared to patients who receive a placebo.
Your question raises complex issues, so my reply is just the basics, and only deals with quantitative data. I do not know about the extent to which hypothesis construction might be helpful in qualitative research. Perhaps other researchers can help out here?
You are very welcome Yogi. I forgot to say that the best scientific outlook to have when you test a hypothesis is to be systematically skeptical regarding speculations of what you might think is true or not. This helps a researcher to avoid finding what she or he thinks she or he is likely to find. Let the mathematics tell its tale.