Neprilysine have been reported to play a crucial role in heart diseases. How can we naturally increase its concentration in our body?
Improving the neprilysin activity in health and disease by dietary measures
(Note: Increasing the activity of enzyme neprilysin has detrimental effects on cardiovascular health, while a decreased level improves the survival in people with heart disease!)
Neprilysin, or neutral endopeptidase (NEP), is an integral type II membrane-bound zinc-dependent metallopeptidase that degrades a number of physiological peptides involved in processes such as blood pressure regulation and nociception (1)
Neprilysin activity is increased in obese people and those with metabolic syndrome. Therefore, low fat, low caloric diet can help reduce the Neprilysin activity in such patients (2).
Increased neprilysin activity has been associated with poor prognosis in people with heart failure and reduced ejection fraction (HFrEF) and a drug with neprilysin inhibitor activity (Sacubitril) in combination with valsartan has shown to improve the symptoms and mortality of patients with HFrEF (4).
1. Article Amino acid sequence of rabbit kidney neutral endopeptidase 2...
2. Article Neprilysin, obesity and the metabolic syndrome
3. Article Low-fat hypocaloric diet reduces neprilysin in overweight an...
4. Article Sacubitril/Valsartan in Management of Heart Failure: A Revie...