Can anybody please suggest me some good papers on in vitro ADME study?

More Urjita Sheth's questions See All

My protein pdb file has omitted certain amino acids. How can I fix that?

I wanted the whole protein structure of beclin-1 protein, but since I could not find he whole protein structure on it's own, I went for the structure of PI3KC3-C1 complex, which included the whole...

22 May 2024 7,717 1 View

I am facing an error in glg file generation in autodock, can anyone help me?

Hi everyone, I am using Autodock and I'm fairly new and unskilled in it. I was performing a protein-ligand dock. I prepared the protein and ligand, saved them in pdbqt, prepared the gpf file and...

22 February 2024 760 2 View

Alternative to ZTP models?

Hi all, I was wondering if anyone knew of alternatives to zero - truncated poisson (ZTP) models. I am trying to fit a regression model using demographics on the ZTP. ZTP is doing okay, except the...

27 April 2023 1,574 4 View

How to perform PVT variation for CMOS circuit in LTspice?

What are the commands used for PVT variation analysis for CMOS circuit in LTspice?

25 September 2021 1,843 10 View

What is the best way to create a Vector file for any figure?

Some journals ask for a vector file for the figures/diagrams submitted for the article. What is the best way to create a vector file from your Microsoft Excel chart?

01 February 2021 6,601 2 View

Is it possible that the strain hardening exponent(n) for Aluminium 1060 alloy is greater then 0.3?

I have got the strain hardening exponent value 0.5637 according to ASTM E646 standard.

29 April 2019 3,302 3 View

How to give rotation to any circular plate in LS-DYNA?

I want to give rotation of 20 rev/min to 0.9mm thick sheet of different aluminum grade blanks.(Axis of rotation is about X-AXIS)

19 November 2018 533 4 View

What are different methods to transform real value metaheuristic algorithm into binary coded algorithm?

I want to use Firefly algorithm for feature selection. Can anyone help in suggesting different transformation methods?

14 September 2018 9,062 4 View

The plasticity index should be equal to or less than 6 for the reinforced fill as per IRC for approaches of fly over. Why?

Plasticity Index. The internal angle of friction should be equal to 25 degree Why? These are the I RC for construction of Reinforced earth wall.

13 August 2018 6,084 4 View

What is personality disorder? Which one is the worst?

Type of the personality

16 April 2018 8,825 17 View

Is there a way to get the distribution, excretion (ADME) compound database?

Is there a way to obtain a compound database containing information of vdss, bbb (blood brain barrier), ppb, Fu (unbound fraction), half life, and clearance corresponding to distribution,...

25 December 2022 4,937 2 View

At what pH is iLOGP calculated in the SwissADME tool/server?

The swissADME tool can calculate iLOGP for a compound. What pH is this measured at?

27 October 2022 5,546 2 View

Can anyone suggest me any software/webserver to predict the ADME/Tox properties of peptides?

28 April 2020 994 1 View

Which are the best ADME assay predictor tools available online?

I am planning to perform a MD simulation and is planning to look for their ADME properties.

19 April 2020 3,062 9 View

What hepatocytes are the best to use for prediction of in vitro drug clearance?

Hi all, I'm working on ADME of some potential drug and I'm looking for the best way to determine in vitro clearance in hepatocytes. As far as I understand, HepG2 cell line was used in past but...

12 November 2019 3,191 3 View

Automated drug dosing systems for ADME-tox/PKPD exps?

Hi All, I was wondering if anyone had experience of working with automated systems for drug dosing for discovery experiments. I want to run ADME-tox type experiments on multiple drug...

20 October 2019 1,106 2 View

Automated drug dosing systems for ADME-tox/PKPD exps?

Hi All, I was wondering if anyone had experience of working with automated systems for drug dosing for discovery experiments. I want to run ADME-tox type experiments on multiple drug...

09 October 2019 1,258 2 View

Hi !! Is there anyone who is using Swiss ADME ? Suggest any other bioinformatics tool for drug-likeness?

I used Swiss ADME few days back . Now I have to do analysis but it is not working.

18 August 2019 4,896 1 View

What is the correct phenol red permeability through Caco2 monolayer?

Dear all, I am performing Caco2 permeability experiments using transwell inserts and I am using phenol red permeability assay to verify the monolayer integrity. What is the maximum phenol red...

06 March 2019 6,894 6 View

What is the correct phenol red permeability through Caco2 monolayer?

Dear all, I am performing Caco2 permeability experiments using transwell inserts and I am using phenol red permeability assay to verify the monolayer integrity. What is the maximum phenol red...

02 March 2019 8,840 4 View

Barbara G. Wells

This may be a good place to start. Good luck.

Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro-in vivo extrapolations (IVIVE).

(PMID:17968734)

Gibson GG, Rostami-Hodjegan A

Xenobiotica; the Fate of Foreign Compounds in Biological Systems [2007, 37(10-11):1013-1014]

Type: Editorial, In Vitro

DOI: 10.1080/00498250701649873

Urjita Sheth

@Barbara G. Wells thank you so much mam

this will be of much help to me