Can any one suggest the best method for global dna methylation in blood and tissue samples ?

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Ana Paula Lepique

I do not, but I recommend you read the papers from Daniel Carvalho's laboratory at the University of Toronto. He is an expert.

Antoine Molaro

I would perform Whole Genome Bisulfite Sequencing. There is already a reference methylome in human (and primate) blood from primary cells. https://www.cell.com/molecular-cell/fulltext/S1097-2765(11)00676-9

Its cheap (assuming your sequencing platform is cheap) and reliable.

I would also get in touch with the primary author of this study, she can provide some critical help and she is quite amazing.

Hope it helps, good luck.

Best.