The answer depends on what you mean with SNR in the MIMO scenario. One can compute the SNR from one transmit antenna to one receive antenna in exactly the same way.
You can also consider the SNR of the MIMO system for a particular transmission method. You select a precoding vector at the transmitter and a combining vector at the receiver. This will effectively turn the channel into an SISO channel and you can now compute the SNR.
By the way, you need to divide by the noise power as well. I recommend my video about SNR computations: https://youtu.be/OA4viERrlzA
1) estimation of noise levels in I and Q receiver channels after turn-off transmitter or by a short circuit on the inputs receiver channels. For such estimation can be used traditional statistics methods, after an analog-to-digital conversation of noises.
2) estimation of amplitude of signals by using in the spatial and frequency domain the Maximum Likelihood estimation method, such as used in this article:
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