Can any one please suggest me how to Derivatize DMSO soluble compound like metabolites and organic compounds for GC-MS analysis ?

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Shashi Kant Bhatia

Hi Ajay

You can use BSTFA or MSTFA derivatization method to analyze amides, secondary amines, hydroxyls group. Here is the link you can visit for further information

https://www.sigmaaldrich.com/content/dam/sigma-aldrich/migrationresource4/Derivatization%20Rgts%20brochure.pdf

Markus Christ

Hi Ajay, this thread maybe helpful to you.

https://www.researchgate.net/post/GC-MS_why_is_extraction_and_derivatisation_usually_done_in_two_steps?_ec=topicPostOverviewFollowedQuestions

It contains literature related to derivatization reactions.

Regards

Markus