For my MD simulation I HAVE SOME QUESTIONS. 1) Can morphine penetrate through cell membranes especially blood-brain barrier itself too or it is common for M6G and M3G to pass through BBB?

2) WHATS YOUR SUGGESTIONs for the composition of my model membrane?

If I WANT TO USE BBB composition which phospholipids are suggested..Is there any cholesterol in BBB ? I should notice that I want to consider the composition as much similar to reality as possible.

Do you have any other suggestions for me?

Thanks in advance

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