if we are using 2microgram/ml of X(adjuvant) NPs and 1microgram/ml of Y(a nucleoside analogue) NPs for synergy analysis in vitro. Then for In vivo studies how the doses should be correlated?
Say for example, 2microgram/ml of X(adjuvant) NPs and 1microgram/ml of Y(a nucleoside analogue) giving synergy in invitro conditions in HCT-116 cells, to substantiate the finding in vivo xenografts the how the doses should calculate in mg/kg so that the combination of both the NPs work in a synergistic manner?
Generally the rate of release in vivo was slower than in vitro by a ..... calculating the prospective area under these data for each.
Determination of dose depends on the titer(number of microorganism,killed or inactivated or live one,used with adjuvant or not)all these play a role in determing the correlations between in vitro and vivo one
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