Hello. Recently, I want to inject the adenosine in vivo to see its effect on the behaviors. But I am not sure whether it can cross blood-brain barrier. If it could, I would choose easier drug-delivery way such as i.p. injection. Could any expert give some advises? Thank you.
radiolabel the amino acid with tritium. The levels of that amino acid in vivo will saturate the level you dose.
Dear Ju Jun,
Adenosine does not cross the blood brain barrier. When adenosine enters the circulation, it is rapidly broken down by adenosine deaminase, which is present in red blood cells and the vessel wall. Thus, adenosine has an extremely short half-life. Therefore, you will need to apply adenosine directly into the brain region as close as possible.
best wishes,
Refik
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