Dear Pedro Ramos to reduce glucose is not sufficient to my opinion, we must reduce calories too. Fasting has demonstrated to control tumor growth better than glucose deprivation. it is a question that my Group is studying and we think to adopt a diet with low glucose more rich in omega 3 fatty acids and with two or 3 days of calories reduction. we think also to use natural inhibitors of glucose like citric acid and thioctic acid (see metabloc)

Pedro: There are a few Pub Med articles (some noted below) related to your question and seemingly in support of your question ...nothing definitive but cause for optimism that this might be an area further research is needed, especially when tied with Caloric Restriction. Anecdotally, the diets themselves are difficult to adhere to

mouse trials- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673985/pdf/pone.0065522.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819381/pdf/1743-7075-4-5.pdf

pediatric case report -

http://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+a+ketogenic+diet+on+tumor+metabolism+and+nutritional+status+in+pediatric+oncology+patients%3A+two+case+reports

Dear Pedro Ramos to reduce glucose is not sufficient to my opinion, we must reduce calories too. Fasting has demonstrated to control tumor growth better than glucose deprivation. it is a question that my Group is studying and we think to adopt a diet with low glucose more rich in omega 3 fatty acids and with two or 3 days of calories reduction. we think also to use natural inhibitors of glucose like citric acid and thioctic acid (see metabloc)

Hi. Yes. Caloric restriction has shown to have major impact on the life spawn and health of organisms. Reading a molecular and cellular physiology textbook helps to understand the mechanism by which caloric restriction influences the death triggers of cells and protein turn-over mechanisms.

So, the organism tries to maintain a stable blood glucose but if this has no meaning then caloric restriction would have no effect whatsoever on people's health.

Blood glucose may be reduced trough low carbohydrate diet but blood available ketone bodies may perhaps compensate for the decline in blood glucose?

I didn't meant this as a cure for cancer, but perhaps can help.

decreasing glucose introduction for example 50 mg of glucose day, you oblige body to do ketone bodies if you use omega 3 fatty acids you fournish energy but not loved by cancer cells, if you get fasting for example in the evening (remember that probably anabolic phase is during night and tumors growth more during night than day ) [this to my opinion may become important in therapytoo] probably is possible not tu cure cancer but helping many therapies to obtain better results. For the aspects of fasting see the works of Longo Walter D,

Gianfranco, that is very interesting. Maybe that is why many people do not feel good when eating too much at night. They just nibble something, because the body, somehow "says" that its not correct. I see this specially in women.

Then, what about effects of light manipulation and hypoxia ?

dear Pedro,for the moment I have not answer for hypoxia but for light manipulation you can have answers from the works of Reiter on melatonin. Hepatocarcinoma in mice decrease if you take during night melatonin. Probably hypoxia is more present during tumor growth and probably during night, but i am not sure.

genetic feeding method, ancient Asians tooked only rice all three times/day.based on genetic make up of person metabolism different. invitro study is different invivo and patients variation also there, avoiding free radicles rich complex food to be good

There are many factors to study other than just a glucose free diet. A person's genetic trait, the lifestyle, physical activity, immunity all come together to fight against cancer plus of course the medications taken and the site of cancer. Plus you cant keep the brain cells feeding on ketone bodies for a long time and a few days of a ketogenic diet will not kill cancer cells, chemotherapy barely kills them in a short period.

I agree Sandy but first of all cells eat, and immune system too is metabolic influenced in cancer.

There are some additional beneficial aspects of dietary restriction. Most of the immune cells localize in the gut-associated lymphoid tissue (GALT) where they "fight" against microbes, undigested proteins and toxin-related damage. So dietary restriction reduces these pathological processes in the digestive tract and immune system has more resources to beat cancer. Similarly, liver and other RES tissues have more energy to catabolize tumor related by-products and increase body-performance. Therefore I believe, thta anti-tumour calorie restriction effect can not be explained by cellular metabolism (Warburg effect etc). It beneficially affects the whole system.

Vytautas Kulvietis, would you be able to provide some references for this? I would be interested in investigating the effects of this kind of diet, combined with exercise, on cancer growth.

Dear Pedro Ramos Reis,

I wish you all the best in your research. Here are some related refs:

Exercise and caloric restriction (CR) modulate immune cells:

http://www.ncbi.nlm.nih.gov/pubmed/23576853

CR alters NK cell function:

http://www.ncbi.nlm.nih.gov/pubmed/23241894

CR reduces pathologic processes associated with cancer (Review):

http://www.ncbi.nlm.nih.gov/pubmed/23924667

CR protects against fatty liver formation:

http://www.ncbi.nlm.nih.gov/pubmed/21977315

CR alters Protein Acetylation in the Liver:

http://www.ncbi.nlm.nih.gov/pubmed/24008504

My favourite (1976). CR doubles the lifespan of mice:

http://www.ncbi.nlm.nih.gov/pubmed/1063408

I believe that people eat too much and it causes diseases.

:) Thank you. This is great literature. I'd like to research this in people. Not mice.

If someone is interested in collaborating in this research, please contact me.

I've found this article. Quite interesting !

Article Fasting Cycles Retard Growth of Tumors and Sensitize a Range...

Interesting article with many therapeutic considerations to do.

In addition to limiting the supplies of glucose and fructose that fuel cancer cell growth, a high-fat/ketogenic diet will facilitate absorption of Vitamins D (D deficiency is linked to cancer and many other diseases) and K (see this link: http://www.ajcn.org/cgi/content/abstract/ajcn.2009.28691v1).

Check out the links on Barry Groves site: http://www.second-opinions.co.uk/cancer_index.html#.UoUZMycsmSo

Some other useful links:

http://www.ncbi.nlm.nih.gov/pubmed/20647326

http://www.ncbi.nlm.nih.gov/pubmed/20664930

http://online.wsj.com/article/SB10001424052970203278404574413273870984920.html

http://www.healthscout.com/news/1/629542/main.html

http://www.reuters.com/article/idustre6714zh20100802?Utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+reuters%2fhealthnews+%28News+%2F+US+%2F+Health+News%29

http://www.ncbi.nlm.nih.gov/pubmed/18502035?ordinalpos=1&itool=PPMCLayout.PPMCAppController.PPMCArticlePage.PPMCPubmedRA&linkpos=1

http://www.ncbi.nlm.nih.gov/pubmed/20455855

http://www.ncbi.nlm.nih.gov/pubmed/18485806

http://www.ncbi.nlm.nih.gov/pubmed/18325755

http://www.cancer.gov/think-tanks-cancer-biology/page8

The above articles relating cancer and inflammation makes sense as grains are highly inflammatory. The best kind of low-carb diet eliminates grains.

Disclaimer: I have a PhD in Geochemistry. No formal medical training.