Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.
Respiratory disorders
Aspirin-induced asthma is an uncommon but very important manifestation of aspirin and NSAID hypersensitivity. It occurs more frequently in patients with asthma who have nasal polyps. Initial studies suggest that CSIs are safe in patients with aspirin-induced asthma, the disorder appearing to be linked to COX-1 inhibition
https://www.mja.com.au/system/files/issues/176_07_010402/bar10002_fm.pdf
Hypoprothrombinaemia could be induced by high doses of aspirin and that could be account for the hypocoagulability .Aspirin blocking the activity of vitamin K1-epoxide reductase,so prevention of vitamin K1--an essential co-factor in the gamma carboxylation of glutamate residues of clotting factor II,VII and X and casues Hypoprothrombinaemia
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