What would be the best way to preserve exhumed human bones (in archaeological or forensic contexts) for downstream decontamination and genetic extraction + analysis?
For example, a specific analytical grade buffer or other chemical solution to submerge the specimen, the most ideal temperature (RT, -20C, -80C, etc.).
Dear Tatyana Laletin I think I can help you with this issue. Snedecker et al. (2025) just published a paper about downstream processing methods for challenging skeletal samples (https://www.fsigenetics.com/article/S1872-4973(24)00205-9/abstract).
If you wish to store the remains for future DNA extraction, you may consider materials listed here: Article An Overview of Conservation Methods for Human Skeletal Remai...
On the same note, Brock et al. (2018) (listed in my paper above), discuss reversible consolidation/restoration methods.
Best,
Maria
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