I want to cote a tablet for colon targeting. Which is the best agents for such task? because pH varies from stomach to colon, so which type of agent is best for such operation?
Reading these articles will help you
▪️doi: 10.1208/s12249-015-0350-9
▪️doi: 10.5001/omj.2010.24
More study esults suggested that colon-targeted acetylharpagide tablets deliver the drug to the colon. The in vitro performance of colon-targeted acetylharpagide tablet was appropriately correlated with its performance in vivo
of drugs from the colon is monitored by colonoscopy and intubation. Currently, gamma scintigraphy and high frequency capsules are the most preferred techniques employed to evaluate colon drug delivery systems
route is the most convenient and preferred route but other routes for CDDS may be used. Rectal administration offers the shortest route for targeting drugs to the colon
Targeted drug delivery is a type of drug delivery system in which the medication is transported or concentrated selectively at the site of action to localize the interaction of drug with diseased site and to avoid the harmful effects to healthy tissue due to drug interactions
drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs
Coatings of Eudragit S may be used to target the release in colonic pH as this polymer is soluble at alkaline pH . The blends of Eudragit S and L can be used for colon targeting
Eudragit polymers are best candidates to target different part or regions from intestine to colon. Further, E, L, S, RS derivatives are linked to PH Specific region to target in these organs.
Colon-targeted drug delivery system is designed by using pH-dependent polymers such as cellulose acetate phthalates (CAP), hydroxypropyl methyl-cellulose phthalate (HPMCP) 50 and 55, copolymers of methacrylic acid, and methyl methacrylate (e.g., Eudragit® S 100, Eudragit® L, Eudragit® FS, and Eudragit® P4135 F). Particularly, Eudragit® polymers are the most widely used synthetic copolymers for colonic drug delivery that offer mucoadhesiveness and pH-dependent drug release. For further details refer: https://doi.org/10.3390/pharmaceutics12010068
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