Newer basal insulins have a very long half-life; eg: Degludec
[t1/2 of 40 hours]
Why does the insulin not 'stack' if it is given daily, but with a 40 hour half-life?
Are they safe to use and how do they compare to Glargine and Detemir?
How do we make this insulin ''safe'' to administer
What is your experience and opinion, please?
The long half life of Degludec should be a problem, but the manufacturers insist that the chemical structure in vivo gives off a steady slow release that doesnt lead to stacking. Changing the dose just changes the set point of release.
It is an interesting concept
What are people's experiences?
Insulin Degludec it safe, it is associated with a lesser nocturnal hypoglycemia compared to other long acting analogues.
Yes, insulin degludec is safe. Please take a look at the following RG link and PDF attachments.
Article Degludec insulin: A novel basal insulin
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