Most therapeutic strategies use inhibitors to target a specific function. Are there examples where a drug induces upregulation of a gene? I'm specifically interested in examples in fungi.
Histone deacetylase inhibitors (HDACIs) prevent the processes involved in the formation of transcriptionally inactive heterochromatin and are used therapeutically in cancers. Not sure to what extent they have been tried in fungi, though.
One can classify the Death receptors or supressors of Programmed cell death in bacterial systems. These genes if upregulated can result in a disequilibrium and cause death of fungi.
In cancer, epigenetic drugs like HDAC-Inh and DNA methylation inhibitors are being used in trials and treatment - both activate genes and cause derepression of tumor supressor genes that are commonly silenced in cancers.
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