Hi Zahid,

Some people have speculated that the occasional case of Creutzfeldt-Jakob disease might be attributed to translation errors or defects, but the majority of prion disease cases are based on protein misfolding.

PubMed has over 20,000 papers on prions with lots of good reviews that explain the basics.

Here is an older one, but you can get it for free:

http://www.pnas.org/content/95/23/13363.full.pdf?sid=0695ce4c-565d-4f23-8478-4372a737a638

Hi Holger 

Thanks so much for  your explanation