As mentioned by Ho et al. (2021), there are no universally-agreed allowable error goals for defining the acceptance criteria for assay interference. Based on their study, they compared multiple acceptance criteria for defining assay interferences based on five separate sources as their basis. The sources of HIL interference acceptance criteria that they adopted were assessed depending both on their clinical relevance and analytical criteria. Aside from the five sources that they have adopted, are there any other published standards or criteria that can be used for assessing HIL interference in chemistry assays?

Reference Article:

Ho, C. K. M., Chen, C., Setoh, J. W. S., Yap, W. W. T., & Hawkins, R. C. W. (2021). Optimization of hemolysis, icterus and Lipemia interference thresholds for 35 clinical chemistry assays. Practical Laboratory Medicine, 25. https://doi.org/10.1016/j.plabm.2021.e00232

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