Hi Bill,

Long time no see. We should catch up. Good to see you are doing so well. 

I am afraid I cant really help you on this issue. I simply dont know enough.

Sid

Hey Sid:  Great to hear from you.  [email protected] is a good email for me. Let's catch  up!

Hi Bill

 If childhood obesity is not related to any other disease, it is better to use  diet and exercise therapy. Shaping behavior step by step, is an another method. childhood obesity rather to prevent than to cure.On the other hand if obesity is related to some other disease then it might be cure by special drugs. 

Bill, good question. The answer might, however, start with what is causing the obesity (and with it the hyperinsulinemia-effect that brings on the weight gain and eventually diabetes in these kids). I would hope that we do not think in terms of leaving the status quo of diet, lifestyle, hydration, etc. in place while just adding a powerful stimulant to burn more calories in the young person. We are of the opinion that current trends in the US to use a drug is the absolute wrong way to go for just about anything in children save infection and in acute events. Instead, we would like to see a campaign to do away with GMO high fructose, a more gluten-free diet (getting rid of the GMO-infused 24-chromosome wheat that has been foisted upon an unsuspecting public and going back to the more primitive 14-chromosome low-gluten wheat), stepping away from microwaved and processed foods and more into paleo and organic, and in drinking water instead of hyperactive Red Bull and Power drinks. When we see the current generation of obese individuals--and it is an incredibly fast growing population--we see ubiquitously the above offenders of good health coupled with sedentary lifestyles void of physical exertion. When the discussion starts there, then we can parse through if there is even a single safe pharmaceutical to aid the effort. So far, we have not found it without introduction of medication-induced adrenal depletion, metabolic acidosis, chronic dehydration, sleeplessness, corticosteroid production and dependency into the equation.  

What a complete answer.

Yes, Metal based nanomedicine are partially helpful for childhood obesity and that could reduced oxidative stress.  

Soumendra, what are the long-term effects of nanmedicines? Would juicing vegetables and recipes for low-calorie smoothies with fruit and vegetables be a better venue for adding antioxidants to reduce oxidative damage?

Below are several studies on dietary interventions for obese children and the last study is exercise lowing oxidative stress markers:

http://www.ncbi.nlm.nih.gov/pubmed/24310523

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676851/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621572/

Many people are not aware that fresh, uncooked fruits and vegetables are also chelates that remove heavy metals to a certain degree. So, Brenda has a point, and the larger point is their getting the nutrition that is so sorely missing with these obese kids. That's why I cannot imagine just recommending a hyperactive drug for their problem. These kids are metabolically imbalanced, and starving for nutrients. They have been given by the adults in their lives gluten-rich wheat products, deadly non-fat additives, artificial sweeteners that eventually kill the animals they are tested on, artificial colorings and flavorings that rattle the nervous system and immunology, and synthetic vitamins that are more toxic than nutritious. Obviously, many have damage to their DNA and to their MItochondrial DNA. Their telomeres are shorter, and inflammation, including inflammation of the cortex, permeates their bodies, not to mention a terrible self-image that leads them to alcohol, drugs, tobacco, and high caffeine. I say, whether it is a cancer victim, a diabetic sufferer, or an obese individual, always, always start by getting them healthy. Usually what is left over after that is accomplished is not such an impossible road to travel. But leaving all of that in place and going for the next diet pill is a formula for disaster for them and an unbelievably deep trough of profits for the drug companies that devise such a scheme.  

In the case of childhood obesity, guidelines have been issued regarding pharmacological treatment of this condition [Batch JA, Baur LA. Management and prevention of obesity and its complications in children and adolescents. The Lancet 2015]. At present, counter-obesity drugs are to be used contextually  abd depending upon the primmary condition of the child/adolescent. Only 10% of the childhood obesity has a known ethiology. But the 90% remaining are due mainly to lifesyles, food habits and engagement of the child/adolescent (and his/her family) in non-healthy practices. So the main therapeutic goal would be to make these children and adolescents to embrace sound food and dietetic practices, physical exercises, regularization of the daily life cycles with emphasis in the diurnal-nocturnal cycle and better rest and sleeping times. And above all, to make the child/adolescent (and by extension their families) aware that it´s up to them the achievement of a healthy, free-of-disease, productive and rewarding life.

If a medical preparation was more effective than "education" why not use it? My clinical experience with utilizing intensive dietary education is that it will work for a few months and then become ineffective. Real treatments to prevent the long-term adverse metabolic effects of childhood obesity (e.g. long lasting epigenetic alterations) should rely on evidence based medicine not philosophy.