Are there advantages to mucosal immunization for respiratory pathogens?

19 May 2020 0 7K Report

A few years ago the Grand Challenge in Global Health project I was working on published the results of a phase I clinical trial for a dry powder vaccine administered via inhalation. Here is the referenceArticle Successful respiratory immunization with dry powder live-att...

and here: Article Safety and immunogenicity of dry powder measles vaccine admi...

Can anybody discuss the relative safety/efficacy advantages of vaccines administered to the mucosa vs parenterally administered vaccines? I see that Moderna is using mRNA to transiently express the spike protein for SARS COV2 as a vaccine candidate, but not sure how it is being administered.

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