The abstract indicates that the HFABP might have value with the hs-cTn(I,T) assay. The cTn(I,T) assay would have the highest sensitivity at 99th pctile, even more tha the combined cTn, HFABP. However, the combined assay might be more in agreement with actual diagnosis. The sensitivity of the hs cTn's has been problematic only because of the assumtion that one test is sufficient - when there is Type 1 and Type 2 AMI (based on plaque rupture). I don't concern myself with intervention complications. The ROC curve has to be based on the total evaluation arricing at the "candidate" diagnosis. What is the basis for the diagnostic variable used to evaluate the predictive analytes. Is it the case that all patients were NSTEMI, and what proportion had ST depresion or T wave invewrsion, or neither? Was the Goldman definition of STABBING useful to exclude MI. Finally,were there such observations as obesity, type 2 DM, cardiomyopathy, history of arrhythmia included in the information database.
Article Comparison of contemporary troponin assays with the novel bi...