I have prepared solutions of different concentrations of the same nanoparticles in DMSO and I am evaluating their antibacterial potentials. I want to know the stability time of these solutions. Will there be any effect on their potential?
Nanoparticle solutions are thermodynamically stable if not oversaturated. However, you likely mean nanoparticle dispersions (if dissolved there are no particles anymore). These are thermodynamically unstable, but may be well stabilized kinetically. So the answer depends on the actual system. Further a predominant antibacterial mode of action is through dissolution of heavy metal ions in water. The dispersion in DMSO will likely have its antimicrobial action due to the DMSO itself.
you should store the nanoparticle solution for several months at room temperature (eg., 3 months) and measure the polydispersity index (pdi) and size of nanoparticles (DLS particle size). Now, if you get similar results to the original sample (before storage) then the stability of the solution is more than 3 months.
Again, a nanoparticle solution means nanoparticles are dissolved, no particles left.
you can capped nanoparticles and keep them stable for several months( time varies with nature of capping agent and contions). i agree with Sobisch also.
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