Thanks alot Mr. Nasir
that link was useful
Herbert I. Rettinger, MD, also conceded that poorly controlled blood sugars and confounding illnesses, such as renal and cardiac conditions, are common in patients with long-standing diabetes, but “there is a huge population of patients with type 1 diabetes, and very few seem to be more susceptible to infection. Perhaps I am missing those with poor diet and glucose control.”
Thanks prof. Rodolfo
so the best recommendation for those how take medications to stop taking them during infection ,best regards, Waleed
Corona virus over-activates the insulin pathway due to the excessive activation of the mTORC1 pathway for excessive reproduction, so the use of drugs in patients not dependent on insulin causes complications unlike patients who depend on insulin
Waleed Kassar
From American Diabetes Association [ https://www.diabetes.org/covid-19-faq ]:
"Are the risks different for people with type 1 and type 2 diabetes?
In general, we don’t know of any reason to think COVID-19 will pose a difference in risk between type 1 and type 2 diabetes. More important is that people with either type of diabetes vary in their age, complications and how well they have been managing their diabetes.
People who already have diabetes-related health problems are likely to have worse outcomes if they contract COVID-19 than people with diabetes who are otherwise healthy, whichever type of diabetes they have."
Dr. Yuan @
Thanks for your answer
Corona virus is highly proliferative so it consume alot of glucose, with more detail it might helps to know virus mode of action especially contributing with mTOR pathway
Dr. Yuan-Yen
Is this the case? what about the immune response in T1D patients, if there is any role or not in COVID-19 susceptibility.
Yuan-Yeu Yau
Insulin dependent patients where, insulin considers as anabolic hormone that's in contrast to cronaviruse proliferation which depand on catabolic action to proliferation @Yuan-
best regards
Waleed
Huda Hadi Al-Hasnawy That is a good question. As we know that this coronavirus is a novel one, a lot of questions are waiting for scientists to answer. This needs some time.
Waleed Kassar Do coronavirus need energy to survive (ex. replication themselves)? Where is this energy from? Hijack from host cells?
Yuan-Yeu Yau
Yes, coronaviruses do
energy come from catabolism action
it is controlling a cell as like genetic mutation
https://www.healio.com/endocrinology/diabetes/news/online/%7B19b3e970-b54c-499b-8cfa-01591e7bcd6b%7D/extra-insulin-supplies-medications-advised-for-people-with-diabetes-in-wake-of-covid-19
Dear, the type 1 diabetic patients may be more vulnerable to COVID-19 because is highly immune and genetically induced than type 2 which life style changes can improve the well being of the patients and immmunological stability of the patients.
Dear Emmanuel Ifeanyi Obeagu
Diabetic patients both types 1 and 2 are more vulnerable to develop serious or critical case of COVID 19 due to insulin metabolism defect and consequences. Considering that cronaviruse replication mechanism it goes in contrast to insulin pathway, So I hypothesized that type 1 is lower in risk than type 2 giving spot of light that might help.
https://www.medicalnewstoday.com/articles/covid-19-and-diabetes
How does COVID-19 affect people with diabetes?