11 September 2020 0 3K Report

I fitted a Cox proportional hazard model and checked the proportionality assumption using R's cox.zph function, with the following output:

chisq df p

Var1 0.0324 1 0.857

Var2 0.1972 1 0.657

log(var3) 4.1552 1 0.042

Var4 4.6903 1 0.030

Var5 0.6472 1 0.421

Var6 1.2257 1 0.268

Var7 4.9311 1 0.026

Var8 0.3684 1 0.544

Var9 2.0905 1 0.148

Var10 0.0319 1 0.858

Var11 4.0771 1 0.043

GLOBAL 14.2625 11 0.219

In the study, Variable 1 and 2 are the ones I'm actually interested in, whereas the others are only controls. As you can see, the PH assumptions seems to hold for these two covariates, but most prominently not for Var3. Can I still interpret my findings on Var1 and 2 and talking about Var3 add, that this is displays the average effect over the study-time? Or will my coefficients for Var1 and 2 be biased/incorrect?

Thanks in advance!

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