i have been reading some papers to get an idea of this. for example, i am aware that as tumor expand, the cells inside of tumor is exposed to compression forces. But there is a part in the paper which i am not sure if the authors are indicating if the cells at periphery of tumor is exposed to stretching or not. i will quote it below and i hope to get an opinion on this matter..
''Growth-induced or residual solid stress is accumulated within tumors during progression as the growth of proliferating cancer cells strains the tumor microenvironment and stores strain energy (Fig. 1)(2). This stress is evident when one excises a tumor, so that no external loads are applied, and makes a cut along its longest axis. The cut releases the stress and allows the tissue to relax, resulting in simultaneous swelling at the center and retraction at the boundary of the tumor. These relaxations lead to a significant “opening” at the location of the cut (Fig. 3B). The retraction of the tissue is indicative of tension at the tumor periphery. The swelling at the center indicates that the intratumoral region is in compression, which presumably balances the tension at the periphery. The tensile growth-induced stress at the periphery
causes a smooth transition of the circumferential stress from compressive inside the tumor to tensile at the interface with the normal tissue (3).''
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Cell Biology