Dear experts: are all substrains of Bown Norway (BN) derived from the same strain? The most readily available strain is BN/Crl, but the reference genome is built on BN/NHsdMcwi. I was wondering if it's possible that those 2 strains were separately derived from the wild but both happened to be "brown norway".
Thank you!!
Depends on breeding technology followed by the breeder. Brown color is not true breeding, as the colour and pigmentation depends on phaeomelanin type. It is the outcome of stoppage of the stage of oxidation of the melanin. Chances are some blacks are thrown out while breeding the brown rats,needing further assessment of true breeding capability of rats. Dominance/ epistasis and recessivity of the lines involved during crossing must be also considered.
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