1.What is the function of Appendix(Cecal Appendix) in the body?
2.What will happen for a person after Appendectomy?(with Appendicitis)
3.What will happen if the normal Appendix remove?(without Appendicitis)
1- Some authors have shown that the appendix has a function as a lymphoid organ, assisting with the maturation of B lymphocytes. Have a local imune response.
2- the patient will recovery well from appendicitis, but will loose the oportunity for future reconstrutive Surgery.
3- Appendix is used to re-create a 'sphincter muscle' in cases of reconstructive surgery if the urinary bladder is removed and to replace ureter if needed. In the past was routinelly removed during abdominal Surgery. @Amirali Moodi Ghalibaf
appendix is not a rudimentary organ, but rather an important part of the immune system with a distinct function within the gut associated lymphoid tissue different from lymphoid tissue in other parts of the intestine.
Risk of parkinson’s will be reduce if you have your appendix removed!!!!
New information
William Parker, Randy Bollinger, and colleagues at Duke University proposed in 2007 that the appendix serves as a haven for useful bacteria when illness flushes the bacteria from the rest of the intestines. Hence the peculiar features of appendix including its shape, architecture, its location just below the normal one-way flow of food and germs in the large intestine, and its association with copious amounts of immune tissue.
Research performed at Winthrop–University Hospital showed that individuals without an appendix were four times more likely to have a recurrence of Clostridium difficile colitis. The appendix, therefore, may act as a "safe house" for beneficial bacteria, serving to repopulate the gut flora in the digestive system following a bout of dysentery or cholera or to boost it following a milder gastrointestinal illness.
The appendix has been identified as an important component of mucosal immune function, particularly B cell-mediated immune responses and extrathymically derived T cells and as defence to invading pathogens also training the T cells a more targetted immune responses
Though off late recent papers mention that the risk of Alziemer's disease is less in those who had appendectomy done in the past. But again whether it is cause Alziemer's is immune modulated disease and appendix is an important part of gut immune system and due to removal of appendix the immune responses drop or any other relationship , is yet to be proven.
It is a lymphoid organ for defense against the abdominal infections. Nevertheless many people can live very well after its removal
Thank you Sir;
Of course the appendix is a lymphoid organ and one of it's functions is related to the immune system,but what will happen after appendectomy whether because of appendicitis or not?
-Will the patient have any problem after several years?
-Do you know any case/cases that have problem after appendectomy because of appendix removal?
Luis Rodrigo
The appendectomy is generally well tolerated with our problems and negative consequences
Agree that appendix is the Abdominal Tonsil,in children it is perhaps important but not in adults .As mentioned by our colleagues ,I also feel that there are any negative consequences following its removal.I am not mentioning about Technical problems.
Wonder if anybody can throw some light or thoughts about the immunological makeup in children post-appendicectomy. I had a chance to work in an exclusive pediatric hospital in South-West Scotland but didn't know of such implication despite regular pediatric cases for appendicectomy. Comments r welcome. Regards
In addition to the earlier answers, recent studies suggest very early appendectomy may be associated with autoimmune disease development, including inflammatory bowel disease (IBD), rheumatoid arthritis and lupus. This is probably due to an exaggerated immune response, one that has not been adequately primed for appropriate reaction due to the absent appendix - a seat of lymphoid tissue. The 'hygiene hypothesis' applied to IBD may also be applied to this phenomenon. Further, this indicates a possible role of the appendix in "post-natal" immune tolerance, akin to the role of the thymus in-utero.
The other theory put-forth recently is the protective benefit of appendectomy in preventing neurodegenerative disease. The immune response initiated by the lymphoid tissue in the appendix each time they are stimulated result in free radicals, reactive oxygen species and other metabolic byproducts that have been implicated in the pathogenesis of neurodegenerative diseases including Parkinson's. The model of hepatic encephalopathy is a good comparison.
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