I want to control a Shimadzu LC-10 (Controller: SCL-10Avp, pumps: LC-10ADvp, autosampler: SIL-10ADvp) coupled to a Waters Quattro Premier XE with Masslynx 4.1. The LC is connected via a serial port to the PC (COM 1, baud rate 9600).

However, I can not establish a conection of the LC with MassLynx. I receive a "not ready" error with "pump flow is off" or a "time-out at serial port COM 1" error with other baud rates. When I start the pumps manually, the error message does not change. As mentioned, I have tried different baud rates and COM ports in all possible combinations.

Further, I have tested other software programs by which I can control the LC without any problems (same PC, same serial connection). So, I assume that the problems is grounded in the MassLynx settings. I have contacted Shimadzu and Waters (Germany) who both tried to help, but do not have any experience in connecting Shimadzu with MassLynx.

Does anyone have experience with MassLynx and Shimadzu and has any further suggestions for me?

Thanks for your help!

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