Glucose disappearance rate for ITT (KITT; %/min) is calculated as:
KITT=(0.693x100) / t1/2
where t1/2 is the "half life" calculated from the slope of the plasma glucose concentration.
The best calculation of t1/2 is to consider an exponential decrement of glucose concentration after insulin administration. A statistic software can calculate that using an exponential fit on the curve. I personally use GraphPad Prism.
Alternatively, a good approximation is to do a linear regression on the initial decrease of the curve and calculate the time where glucose concentration is 50% of the starting value.
Glucose disappearance rate for ITT (KITT; %/min) is calculated as:
KITT=(0.693x100) / t1/2
where t1/2 is the "half life" calculated from the slope of the plasma glucose concentration.
The best calculation of t1/2 is to consider an exponential decrement of glucose concentration after insulin administration. A statistic software can calculate that using an exponential fit on the curve. I personally use GraphPad Prism.
Alternatively, a good approximation is to do a linear regression on the initial decrease of the curve and calculate the time where glucose concentration is 50% of the starting value.
this link is useful
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020335/
regards
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