Anyone faced issue in Vismeier-Haack formylation of trimethoxy benzene?

Sivaraman Somasundaram @Sivaraman-Somasundaram-2

30 November 2022 0 440 Report

I am trying to synthesis 2,3,4-trimethoxy benzaldehyde from 1,2,3-trimethoxy benzene using POCl3 and DMF. After isolation of crude product, I observed an UV-inactive, Iodine active polar spot in TLC which not allowing the product to crystallize out.

Anyone faced such issue? I would appreciate if your share your experience on this.

Thanks!

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