Statement 1: we got one sample to have HBeAg ELISA and HBV PCR both Positive, indicating active replication present in the HBV virus.
Statement 2: we got one sample to have HBeAg ELISA negative, but HBV PCR positive, is this possible?
Statement 3: we got one sample to have HBeAg ELISA positive, but HBV PCR negative, is this possible?
Does anybody explain this variation and possibility? Can i get any reference?
Thanks in advance to all.
HI,
Yes, that is possible if the patient is not in an active replicative stage but the HBV load is higher. One of the reasons may be if the patient is non-adherence to drugs.
yes, its possible. HbeAg is often positive in acute HBV patients and we can find a direct correlation between the HbeAg status and HBV DNA level. However, asymptomatic, chronic HBV and HBeAg mutants does not follow the pattern. The level of HBV DNA load is the benchmark and the presence or absence of serological marker shall be considered as a supportive guideline with respect to the definition of the clinical stage of each case and treatment.
thank you
Kalyanaraman
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