Hello everyone!
I am looking for an antimicrobial peptide that is active against Bacillus subtilis, and can be produced by E. coli without killing it. Any suggestions?
Thanks!
Daniel
Ive heard there was some research about nisin producing e. coli. I think nisin should be active on B. Subtilis, but i am not certain.
Edit:
"Bacillus subtilis had been suggested as a potential host for the biosynthesis of nisin but was discarded due to its sensitivity to the lethal action of nisin." Hansen et. al.
Worth looking into i'd say!
Principally bacteriocins reduce the growth of bacterial strains that are similar or closely associated. Therefore antimicrobial peptides of E. coli (colicine) cannot inhibit the growth of B. subtilis. Bacteriocins are a kind of ribosomal synthesized antimicrobial peptides and genetic modification of E. coli in order to achieve this goal is required. Considering the differences between Gram-negative and Gram-positive bacteria is essential.
There are several lactic acid bacteria used in vegetal fermentation that produce bacteriocins that controlseveral other groups of bacteria growth I would look there.
- Badges
- Science topic
- Similar topics
- Biological Science
- Bioscience
- Biotechnology