How can I calculate the dose of the antimicrobial agent for poultry if I know just the MIC of that antimicrobial agent?
It depends; age, weight, route of administration and others.
It is not possible to determine the effective dose from the MIC alone. The science of determining the relationship between the dose and its effect is called pharmacodynamics. In vivo experiments are usually required to establish the relationship.
It may be feasible to use a rather complicated in vitro system for antibiotics called the hollow fiber system in place of in vivo experiments to study the pharmacodynamics. In order to use this system, it is essential to first understand the pharmacokinetics of the drug in the animal. Pharmacokinetics is about how the concentration of the drug in the blood or tissue varies with time after administration.
I suggest you consult with an expert in pharmacology to fill out the picture.
For me to get antimicrobial dose, i may decide to do two fold dilution,assuming the weight of the antimicrobial agent is 800mg, i need to change it to gram by dividing 800 with 1000 to get 0.8g, i will measure 4ml of a diluent into a test tube and add the 0.8g to get 200mg/ml,assuming the MIC is 3.125mg/ml, you can find other ones bearing in mind that you did two fold dilution.
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