Hello,
Anyone could recommend me an anti-CDx antibody inducing direct human B cell death apart from CD20 (rituximab) and anti-DR L243?
Thanks
There are a large number of CDs that can induce apoptosis of B cells.
If the most commonly used antibodies are those targeting the FAS / FASL interaction, most B-cell-specific CDs may induce all or part of the apoptosis of B-cell subpopulations.
In one of his articles Laurent Genestier studies the apoptosis induced by antibodies such as Mab4, Mab71, Mab75, Mab90 and Mab91. In this series of antibodies, there is an antibody class I (clone 90), an anti b2microglobulin (clone 4) and an anti CD20 homolgue (clone 75). The most potent antibodies were clones 90 and 91.
Many other antibodies can be used: CD19, CD21, CD22, CD27, CD44, CD71 ... however, care must be taken because an antibody used improperly can have an opposite effect: for example Mab89 (anti CD40) Apoptosis of macrophages and B cells if used in its soluble form, whereas it is very strong activator of the B cells when it is fixed to a support.
Cher Jean-Jacques, Thank you for your reply. Are some of them commercially available? Thanks.
Dear Vincent, some of these antibodies are available from Dendritics (www.dendritics.net).
I suggest you contact Diane Doll [[email protected]], who can redirect you to a US distributor.
But maybe you would be interested in targeting something other than standard molecules. Diane could make suggestions to you.
Regards
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