An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice

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Anthony G Gordon

Traumatic brain injury in humans can be divided into

Specific damage to brain tissue, as shows up on scans, analogous to brain injury after strokes.

Generalized brain damage as can be picked up by tissue products in the blood stream, yet to be shown to be of clinical relevance.

Specific neurological syndromes, as seen in boxers, eg EDH, CTE, etc.

Many animal models have tried to mimic concussion, which I think is irrelevant as it is probably due to temporary dysfunction of the vestibular reflex system originating in the inner ear, and nothing to do with the brain.

Emmanuelle Cugy

Hello, for stroke damage, I think you could find some data/reference in this article about neuroplasticity.

For concussion, you should read the chapter 46 (Animal Models for Concussion) of the book "Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects."

http://www.ncbi.nlm.nih.gov/books/NBK299196/

another recent reference

http://www.ncbi.nlm.nih.gov/pubmed/25684677

Helmut F Novak

May be this can help you: 2001-2004:

FWF-Projekt P15308 "Proteolytic Mechanisms of Traumatic Brain Injury" (Andreas Kampfl)

Andreas Kampfl is head of anestesiologic dept. of

Krankenhaus der Barmherzigen Schwestern Ried BetriebsgmbH

Abteilung Neurologie, Schlossberg 1, 4910 Ried im Innkreis

e-Mail: [email protected]

So I recommend to ask him with best regards

Robin Highley

Speak to these guys: http://www.ncbi.nlm.nih.gov/pubmed/27251042