How do we calculate the loading dose and maintenance dose in development of SR multiple unit pellets (Coated) ?

In some disease conditions the there is lag time to achieve the PDC in the therapeutic range. Therefore, there is need to administered loading dose separately or together with maintenance dose.

09 March 2019 4,691 1 View

What are the challenges for developing protein and peptide drug delivery?

Protein & Peptide Drug Delivery

25 November 2018 6,900 3 View

How can we process image captured under bright light?

Image lighting can change the perception of image characteristics which means that relative to image representations, light changes can result in huge image differences. Using a simple or...

30 March 2014 273 7 View

Could you suggest the method of preparation of nanoparticles free from organic solvent and easy to scale up ?

Drug loaded nanoparticles especially polymeric

01 January 1970 8,896 2 View

Computer Aided Drug Delivery

Reference book or Journal etc

01 January 1970 9,194 3 View

Is there any teachers based in UK who would like to take part in my study?

24 February 2021 4,833 3 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

How can we add reinforced thermoplastics with granules in injection molding machine?

I need to make an injection molding machine in which short fibers are to be introduced. Short fiber length and material properties are to be determined and also the material strength are to be...

22 February 2021 4,290 1 View

What is the optimal method to prepare a controlled porosity osmotic pump (CPOP) tablet for scanning electron microscopy?

In order to assess the shape and size of pores formed by dissolving the pore former in the semipermeable membrane structure, SEM images are needed. Cellulose acetate was used in the coating...

15 February 2021 6,135 3 View

Will rat colon cancer cells (DHD/K12) derived from BDIX rats grow in Sprague Dawley ?

we plan to induce colon cancer by injection. Cell lines derive from BDIX rats, but our experimental setting would favour SD rats. any experience?

23 January 2021 1,437 2 View

Is there a study on the maximum thumb extension that can be possible in a range of population while using injectors?

In Most pen injectors while dialing the dose, the dose dialer comes our or extends outside the pen as dialing happens. How much maximum extension of dialer is acceptable for performing...

17 January 2021 9,770 1 View

How to couple Moldex 3D with MATLAB for design optimization of an injection mould?

Hello, I would like to use the software Moldex 3D for the design optimization of an injection mould. How can I couple Moldex 3D with a MATLAB code? Any help appreciated, I wish you all a happy...

09 January 2021 569 2 View

How to setup ANSYS Fluent for simulating the filling stage of an injection mould?

Hello, I am using ANSYS Fluent for simulating the filling stage of an injection mould. However, when comparing the results with those of specialized software, such as Moldex 3D, I found the...

07 January 2021 7,992 1 View

Do drugs that are injected i.t in rats reach the supraspinal system and how long does it take to clear them from spinal cord?

I am injecting intrathecally (between L5-L6) , in rats, cannabinoid analgesics and I was wondering if they can reach the brain and have effects there as well ? Also I need to pretreat with...

07 January 2021 5,397 4 View

How big the Balb/c mice spleen after immunization?

I am working with Balb/c mice, and in my experiment, I have to inject mice with antigens, then get their spleen and collect the splenocytes for fusion. Recently, I get into trouble with the mouse...

04 January 2021 3,591 3 View